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Anti-MCTS1 Polyclonal Antibody (ARO-A11228)

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概述
货号ARO-A11228
品牌ProteoGenix
描述
Anti-MCTS1 Polyclonal Antibody (ARO-A11228) is a rabbit polyclonal antibody detecting MCTS1, Multiple copies T-cell malignancies, MCT1, MCT-1, Malignant T-cell-amplified sequence 1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human MCTS1 (Met1-Lys181).
靶标MCTS1, Multiple copies T-cell malignancies, MCT1, MCT-1, Malignant T-cell-amplified sequence 1
纯化方式Purified by antigen affinity column.
Accession号Q9ULC4
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Malignant T-cell-amplified sequence 1 (MCTS1) is a ~20 kDa protein. Translation regulator forming a complex with DENR to promote translation reinitiation. Translation reinitiation is the process where the small ribosomal subunit remains attached to the mRNA following termination of translation of a regulatory upstream ORF (uORF), and resume scanning on the same mRNA molecule to initiate translation of a downstream ORF, usually the main ORF (mORF). The MCTS1/DENR complex is pivotal to two linked mechanisms essential for translation reinitiation. Firstly, the dissociation of deacylated tRNAs from post-termination 40S ribosomal complexes during ribosome recycling. Secondly, the recruitment in an EIF2-independent manner of aminoacylated initiator tRNA to P site of 40S ribosomes for a new round of translation.

1. Reinert, LS. et al. (2006) Cancer research 66, 8994-9001. PMID: 16982740
2. Skabkin, MA. et al. (2010) Genes & development 24, 1787-801. PMID: 20713520
3. Bohlen, J. et al. (2023) Cell 186, 5114-5134.e27. PMID: 37875108
4. Dierov, J. et al. (1999) Journal of cellular biochemistry 74, 544-50. PMID: 10440924
5. Herbert, GB. et al. (2001) Oncogene 20, 6777-83. PMID: 11709712
6. Shi, B. et al. (2003) Blood 102, 297-302. PMID: 12637315
7. Hsu, HL. et al. (2005) Oncogene 24, 4956-64. PMID: 15897892
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-MCTS1 Polyclonal Antibody

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