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Anti-BCAR3 Polyclonal Antibody (ARO-A11358)

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概述
货号ARO-A11358
品牌ProteoGenix
描述
Anti-BCAR3 Polyclonal Antibody (ARO-A11358) is a rabbit polyclonal antibody detecting SH2 domain-containing protein 3B, Novel SH2-containing protein 2, SH2D3B, NSP2, Breast cancer anti-estrogen resistance protein 3, BCAR3 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human BCAR3 (Glu533-Leu825).
靶标SH2 domain-containing protein 3B, Novel SH2-containing protein 2, SH2D3B, NSP2, Breast cancer anti-estrogen resistance protein 3, BCAR3
纯化方式Purified by antigen affinity column.
Accession号O75815
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Breast cancer anti-estrogen resistance protein 3 (BCAR3) is a ~92 kDa protein. Acts as an adapter protein downstream of several growth factor receptors to promote cell proliferation, migration, and redistribution of actin fibers. Specifically involved in INS/insulin signaling pathway by mediating MAPK1/ERK2-MAPK3/ERK1 activation and DNA synthesis. Promotes insulin-mediated membrane ruffling. In response to vasoconstrictor peptide EDN1, involved in the activation of RAP1 downstream of PTK2B via interaction with phosphorylated BCAR1. Inhibits cell migration and invasion via regulation of TGFB-mediated matrix digestion, actin filament rearrangement, and inhibition of invadopodia activity.

1. Oh, MJ. et al. (2013) Biochemical and biophysical research communications 441, 911-6. PMID: 24216110
2. Rufanova, VA. et al. (2009) Journal of cellular physiology 219, 45-56. PMID: 19086031
3. Oh, MJ. et al. (2008) Biochemical and biophysical research communications 375, 430-4. PMID: 18722344
4. Mace, PD. et al. (2011) Nature structural & molecular biology 18, 1381-7. PMID: 22081014
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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