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Anti-Human SH2D1B Polyclonal Antibody (ARO-A11376)

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概述
货号ARO-A11376
品牌ProteoGenix
描述
Anti-Human SH2D1B Polyclonal Antibody (ARO-A11376) is a rabbit polyclonal antibody detecting EAT2, SH2D1B, SH2 domain-containing protein 1B, EAT-2, EWS/FLI1-activated transcript 2 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human SH2D1B (Asp2-Gly92).
靶标EAT2, SH2D1B, SH2 domain-containing protein 1B, EAT-2, EWS/FLI1-activated transcript 2
纯化方式Purified by antigen affinity column.
Accession号O14796
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

SH2 domain-containing protein 1B (SH2D1B) is a ~15 kDa protein. Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as CD84, SLAMF1, LY9 and CD244. In SLAM signaling seems to cooperate with SH2D1A/SAP. Plays a role in regulation of effector functions of natural killer (NK) cells by controlling signal transduction through CD244/2B4 without effecting its tyrosine phosphorylation; downstream signaling involves PLCG1 and ERK activation. Activation of SLAMF7-mediated NK cell function does not effect receptor tyrosine phosphorylation but distal signaling. In the context of NK cell-mediated cytotoxicity does not enhance conjugate formation with target cells but stimulates polarization of the microtubule-organizing center and cytotoxic granules toward the NK cell synapse.

1. Morra, M. et al. (2001) The EMBO journal 20, 5840-52. PMID: 11689425
2. Pérez-Quintero, LA. et al. (2014) The Journal of experimental medicine 211, 727-42. PMID: 24687958
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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