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Anti-Human SH3BP5 Polyclonal Antibody (ARO-A11367)

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概述
货号ARO-A11367
品牌ProteoGenix
描述
Anti-Human SH3BP5 Polyclonal Antibody (ARO-A11367) is a rabbit polyclonal antibody detecting SAB, SH3 domain-binding protein that preferentially associates with BTK, SH3 domain-binding protein 5, SH3BP5, SH3BP-5 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human SH3BP5 (Ser10-Glu276).
靶标SAB, SH3 domain-binding protein that preferentially associates with BTK, SH3 domain-binding protein 5, SH3BP5, SH3BP-5
纯化方式Purified by antigen affinity column.
Accession号O60239
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

SH3 domain-binding protein 5 (SH3BP5) is a ~50 kDa protein. Functions as a guanine nucleotide exchange factor (GEF) with specificity for RAB11A and RAB25. Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death.

1. Sakaguchi, A. et al. (2015) Developmental cell 35, 211-21. PMID: 26506309
2. Jenkins, ML. et al. (2018) Nature communications 9, 3772. PMID: 30217979
NoteFor research use only.
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参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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