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Anti-MAPK12 Polyclonal Antibody (ARO-A11386)

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概述
货号ARO-A11386
品牌ProteoGenix
描述
Anti-MAPK12 Polyclonal Antibody (ARO-A11386) is a rabbit polyclonal antibody detecting Mitogen-activated protein kinase 12, ERK6, MAPK12, Extracellular signal-regulated kinase 6, ERK-6, MAP kinase p38 gamma, SAPK3, MAPK 12, Stress-activated protein kinase 3, MAP kinase 12, Mitogen-activated protein kinase p38 gamma in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human MAPK12 (Tyr27-Phe311).
靶标Mitogen-activated protein kinase 12, ERK6, MAPK12, Extracellular signal-regulated kinase 6, ERK-6, MAP kinase p38 gamma, SAPK3, MAPK 12, Stress-activated protein kinase 3, MAP kinase 12, Mitogen-activated protein kinase p38 gamma
纯化方式Purified by antigen affinity column.
Accession号P53778
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Mitogen-activated protein kinase 12 (MAPK12) is a ~41 kDa protein. Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in myoblast differentiation and also in the down-regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation.

NoteFor research use only.
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参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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