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Anti-PAX5 Polyclonal Antibody (ARO-A11450)

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概述
货号ARO-A11450
品牌ProteoGenix
描述
Anti-PAX5 Polyclonal Antibody (ARO-A11450) is a rabbit polyclonal antibody detecting B-cell-specific transcription factor, Paired box protein Pax-5, BSAP, PAX5 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human PAX5 (Met1-His391).
靶标B-cell-specific transcription factor, Paired box protein Pax-5, BSAP, PAX5
纯化方式Purified by antigen affinity column.
Accession号Q02548
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Paired box protein Pax-5 (PAX5) is a ~42 kDa protein. Transcription factor that plays an essential role in commitment of lymphoid progenitors to the B-lymphocyte lineage. Fulfills a dual role by repressing B-lineage inappropriate genes and simultaneously activating B-lineage-specific genes. In turn, regulates cell adhesion and migration, induces V(H)-to-D(H)J(H) recombination, facilitates pre-B-cell receptor signaling and promotes development to the mature B-cell stage. Repression of the cohesin-release factor WAPL causes global changes of the chromosomal architecture in pro-B cells to facilitate the generation of a diverse antibody repertoire.

1. Eberhard, D. et al. (2000) The EMBO journal 19, 2292-303. PMID: 10811620
2. Inagaki, Y. et al. (2016) Biochemical and biophysical research communications 475, 176-81. PMID: 27181361
3. Hill, L. et al. (2020) Nature 584, 142-147. PMID: 32612238
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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