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Anti-AXIN1 Polyclonal Antibody (ARO-A11475)

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概述
货号ARO-A11475
品牌ProteoGenix
描述
Anti-AXIN1 Polyclonal Antibody (ARO-A11475) is a rabbit polyclonal antibody detecting AXIN, Axin-1, hAxin, Axis inhibition protein 1, AXIN1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human AXIN1 (Ser653-Asp862).
靶标AXIN, Axin-1, hAxin, Axis inhibition protein 1, AXIN1
纯化方式Purified by antigen affinity column.
Accession号O15169
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Axin-1 (AXIN1) is a ~95 kDa protein. Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7.

1. Kusano, S. et al. (2002) Molecular and cellular biology 22, 6393-405. PMID: 12192039
2. Goto, T. et al. (2016) FEBS letters 590, 1291-303. PMID: 27098453
3. Lu, Y. et al. (2017) Cell research 27, 1422-1440. PMID: 28829046
4. Liu, W. et al. (2006) The EMBO journal 25, 1646-58. PMID: 16601693
5. Li, Q. et al. (2007) Cancer research 67, 66-74. PMID: 17210684
NoteFor research use only.
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参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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