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Anti-RAB1A Polyclonal Antibody (ARO-A11487)

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概述
货号ARO-A11487
品牌ProteoGenix
描述
Anti-RAB1A Polyclonal Antibody (ARO-A11487) is a rabbit polyclonal antibody detecting Ras-related protein Rab-1A, YPT1-related protein, RAB1A, RAB1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human RAB1A (Met1-Cys205).
靶标Ras-related protein Rab-1A, YPT1-related protein, RAB1A, RAB1
纯化方式Purified by antigen affinity column.
Accession号P62820
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Ras-related protein Rab-1A (RAB1A) is a ~22 kDa protein. The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion. Required to modulate the compacted morphology of the Golgi. Regulates the level of CASR present at the cell membrane.

1. Wang, C. et al. (2010) The Journal of biological chemistry 285, 29398-405. PMID: 20639577
2. Zhuang, X. et al. (2010) Endocrinology 151, 5114-23. PMID: 20861236
3. Mukhopadhyay, A. et al. (2011) Journal of cell science 124, 765-75. PMID: 21303926
4. Dong, N. et al. (2012) Cell 150, 1029-41. PMID: 22939626
5. Aizawa, M. et al. (2015) The Journal of biological chemistry 290, 22250-61. PMID: 26209634
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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