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Anti-ACSL4 Polyclonal Antibody (ARO-A11555)

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概述
货号ARO-A11555
品牌ProteoGenix
描述
Anti-ACSL4 Polyclonal Antibody (ARO-A11555) is a rabbit polyclonal antibody detecting ACS4, ACSL4, Long-chain-fatty-acid--CoA ligase 4, LACS 4, Arachidonate--CoA ligase, FACL4, Long-chain acyl-CoA synthetase 4, LACS4 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human ACSL4 (Lys500-Lys711).
靶标ACS4, ACSL4, Long-chain-fatty-acid--CoA ligase 4, LACS 4, Arachidonate--CoA ligase, FACL4, Long-chain acyl-CoA synthetase 4, LACS4
纯化方式Purified by antigen affinity column.
Accession号O60488
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Long-chain-fatty-acid--CoA ligase 4 (ACSL4) is a ~79 kDa protein. Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially activates arachidonate and eicosapentaenoate as substrates. Preferentially activates 8,9-EET > 14,15-EET > 5,6-EET > 11,12-EET. Modulates glucose-stimulated insulin secretion by regulating the levels of unesterified EETs. Modulates prostaglandin E2 secretion.

1. Golej, DL. et al. (2011) Journal of lipid research 52, 782-93. PMID: 21242590
2. Nakahara, K. et al. (2012) Molecular cell 46, 461-71. PMID: 22633490
3. Ohkuni, A. et al. (2013) Biochemical and biophysical research communications 442, 195-201. PMID: 24269233
4. Shimbara-Matsubayashi, S. et al. (2019) Biological & pharmaceutical bulletin 42, 850-855. PMID: 31061331
5. Li, Z. et al. (2024) Nature chemical biology 20, 1341-1352. PMID: 38720107
6. Doll, S. et al. (2017) Nature chemical biology 13, 91-98. PMID: 27842070
7. Zhang, HL. et al. (2022) Nature cell biology 24, 88-98. PMID: 35027735
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-ACSL4 Polyclonal Antibody

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