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Anti-FDXR Polyclonal Antibody (ARO-A11556)

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概述
货号ARO-A11556
品牌ProteoGenix
描述
Anti-FDXR Polyclonal Antibody (ARO-A11556) is a rabbit polyclonal antibody detecting ADXR, Adrenodoxin reductase, NADPH:adrenodoxin oxidoreductase, mitochondrial, Ferredoxin reductase, Ferredoxin--NADP(+) reductase, FDXR, AR in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human FDXR (Ser33-Arg219).
靶标ADXR, Adrenodoxin reductase, NADPH:adrenodoxin oxidoreductase, mitochondrial, Ferredoxin reductase, Ferredoxin--NADP(+) reductase, FDXR, AR
纯化方式Purified by antigen affinity column.
Accession号P22570
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

NADPH:adrenodoxin oxidoreductase, mitochondrial (FDXR) is a ~53 kDa protein. Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver. Also acts as a ferredoxin--NADP(+) reductase essential for coenzyme Q biosynthesis: together with FDX2, transfers the electrons required for the hydroxylation reaction performed by COQ6.

1. Nicoll, CR. et al. (2024) Nature catalysis 7, 148-160. PMID: 38425362
NoteFor research use only.
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参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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