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Anti-TWNK Polyclonal Antibody (ARO-A11527)

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概述
货号ARO-A11527
品牌ProteoGenix
描述
Anti-TWNK Polyclonal Antibody (ARO-A11527) is a rabbit polyclonal antibody detecting PEO1, Twinkle mtDNA helicase, Progressive external ophthalmoplegia 1 protein, T7-like mitochondrial DNA helicase, TWNK, T7 gp4-like protein with intramitochondrial nucleoid localization, C10orf2, Twinkle protein, mitochondrial in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human TWNK (Val384-Lys635).
靶标PEO1, Twinkle mtDNA helicase, Progressive external ophthalmoplegia 1 protein, T7-like mitochondrial DNA helicase, TWNK, T7 gp4-like protein with intramitochondrial nucleoid localization, C10orf2, Twinkle protein, mitochondrial
纯化方式Purified by antigen affinity column.
Accession号Q96RR1
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Twinkle mtDNA helicase (TWNK) is a ~77 kDa protein. Mitochondrial helicase involved in mtDNA replication and repair. Might have a role in mtDNA repair. Has DNA strand separation activity needed to form a processive replication fork for leading strand synthesis which is catalyzed by the formation of a replisome complex with POLG and mtSDB. Preferentially unwinds DNA substrates with pre-existing 5'-and 3'- single-stranded tails but is also active on a 5'- flap substrate. Can dissociate the invading strand of immobile or mobile D-loop DNA structures irrespective of the single strand polarity of the third strand.

1. Korhonen, JA. et al. (2003) The Journal of biological chemistry 278, 48627-32. PMID: 12975372
2. Korhonen, JA. et al. (2004) The EMBO journal 23, 2423-9. PMID: 15167897
3. Ziebarth, TD. et al. (2007) Journal of molecular biology 367, 1382-91. PMID: 17324440
4. Farge, G. et al. (2008) Nucleic acids research 36, 393-403. PMID: 18039713
5. Goffart, S. et al. (2009) Human molecular genetics 18, 328-40. PMID: 18971204
6. Fernández-Millán, P. et al. (2015) Nucleic acids research 43, 4284-95. PMID: 25824949
7. Sen, D. et al. (2016) Nucleic acids research 44, 4200-10. PMID: 26887820
8. Khan, I. et al. (2016) The Journal of biological chemistry 291, 14324-14339. PMID: 27226550
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-TWNK Polyclonal Antibody

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