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Anti-ABCD4 Polyclonal Antibody (ARO-A11648)

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概述
货号ARO-A11648
品牌ProteoGenix
描述
Anti-ABCD4 Polyclonal Antibody (ARO-A11648) is a rabbit polyclonal antibody detecting ATP-binding cassette sub-family D member 4, ABCD4, PXMP1-L, PMP70-related protein, Peroxisomal membrane protein 1-like, P70R, PMP69, Peroxisomal membrane protein 69, PXMP1L, Lysosomal cobalamin transporter ABCD4 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human ABCD4 (Leu356-Glu606).
靶标ATP-binding cassette sub-family D member 4, ABCD4, PXMP1-L, PMP70-related protein, Peroxisomal membrane protein 1-like, P70R, PMP69, Peroxisomal membrane protein 69, PXMP1L, Lysosomal cobalamin transporter ABCD4
纯化方式Purified by antigen affinity column.
Accession号O14678
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Lysosomal cobalamin transporter ABCD4 is a ~68 kDa protein. Lysosomal membrane protein that transports cobalamin (Vitamin B12) from the lysosomal lumen to the cytosol in an ATP-dependent manner. Targeted by LMBRD1 lysosomal chaperone from the endoplasmic reticulum to the lysosomal membrane. Then forms a complex with lysosomal chaperone LMBRD1 and cytosolic MMACHC to transport cobalamin across the lysosomal membrane.

1. Coelho, D. et al. (2012) Nature genetics 44, 1152-5. PMID: 22922874
2. Fettelschoss, V. et al. (2017) The Journal of biological chemistry 292, 11980-11991. PMID: 28572511
3. Xu, D. et al. (2019) Cell research 29, 1039-1041. PMID: 31467407
4. Kitai, K. et al. (2021) The Journal of biological chemistry 296, 100654. PMID: 33845046
5. Kawaguchi, K. et al. (2016) Scientific reports 6, 30183. PMID: 27456980
6. Deme, JC. et al. (2014) Molecular membrane biology 31, 250-61. PMID: 25535791
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-ABCD4 Polyclonal Antibody

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