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Anti-ALDH1A2 Polyclonal Antibody (ARO-A11665)

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概述
货号ARO-A11665
品牌ProteoGenix
描述
Anti-ALDH1A2 Polyclonal Antibody (ARO-A11665) is a rabbit polyclonal antibody detecting Retinaldehyde-specific dehydrogenase type 2, ALDH1A2, Retinal dehydrogenase 2, RALDH2, RALDH(II), Aldehyde dehydrogenase family 1 member A2, RALDH 2, RalDH2 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human ALDH1A2 (Met1-Val422).
靶标Retinaldehyde-specific dehydrogenase type 2, ALDH1A2, Retinal dehydrogenase 2, RALDH2, RALDH(II), Aldehyde dehydrogenase family 1 member A2, RALDH 2, RalDH2
纯化方式Purified by antigen affinity column.
Accession号O94788
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Retinal dehydrogenase 2 (ALDH1A2) is a ~56 kDa protein. Catalyzes the NAD-dependent oxidation of aldehyde substrates, such as all-trans-retinal and all-trans-13,14-dihydroretinal, to their corresponding carboxylic acids, all-trans-retinoate and all-trans-13,14-dihydroretinoate, respectively. Retinoate signaling is critical for the transcriptional control of many genes, for instance it is crucial for initiation of meiosis in both male and female (Probable). Recognizes retinal as substrate, both in its free form and when bound to cellular retinol-binding protein. Can metabolize octanal and decanal, but has only very low activity with benzaldehyde, acetaldehyde and propanal. Displays complete lack of activity with citral.

1. Chen, Y. et al. (2018) ACS chemical biology 13, 582-590. PMID: 29240402
2. Beecroft, SJ. et al. (2021) Human mutation 42, 506-519. PMID: 33565183
NoteFor research use only.
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参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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