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Anti-MAP1LC3A Polyclonal Antibody (ARO-A11700)

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概述
货号ARO-A11700
品牌ProteoGenix
描述
Anti-MAP1LC3A Polyclonal Antibody (ARO-A11700) is a rabbit polyclonal antibody detecting Autophagy-related protein LC3 A, Autophagy-related ubiquitin-like modifier LC3 A, MAP1 light chain 3-like protein 1, Microtubule-associated protein 1 light chain 3 alpha, MAP1A/MAP1B LC3 A, MAP1LC3A, Microtubule-associated proteins 1A/1B light chain 3A, MAP1A/MAP1B light chain 3 A in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human MAP1LC3A (Met1-Gly120).
靶标Autophagy-related protein LC3 A, Autophagy-related ubiquitin-like modifier LC3 A, MAP1 light chain 3-like protein 1, Microtubule-associated protein 1 light chain 3 alpha, MAP1A/MAP1B LC3 A, MAP1LC3A, Microtubule-associated proteins 1A/1B light chain 3A, MAP1A/MAP1B light chain 3 A
纯化方式Purified by antigen affinity column.
Accession号Q9H492
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Microtubule-associated protein 1 light chain 3 alpha (MAP1LC3A) is a ~14 kDa protein. Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover.

1. Cherra, SJ. et al. (2010) The Journal of cell biology 190, 533-9. PMID: 20713600
2. Suzuki, H. et al. (2014) Structure (London, England : 1993) 22, 47-58. PMID: 24290141
3. An, H. et al. (2019) Molecular cell 74, 891-908.e10. PMID: 31006537
4. Chino, H. et al. (2019) Molecular cell 74, 909-921.e6. PMID: 31006538
NoteFor research use only.
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参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-MAP1LC3A Polyclonal Antibody

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