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Anti-Human CHAC1 Polyclonal Antibody (ARO-A11796)

概述
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参考文献

概述

货号	ARO-A11796
品牌	ProteoGenix
描述	Anti-Human CHAC1 Polyclonal Antibody (ARO-A11796) is a rabbit polyclonal antibody detecting Glutathione-specific gamma-glutamylcyclotransferase 1, Gamma-GCG 1, Cation transport regulator-like protein 1, CHAC1, Botch, BOTCH, Blocks Notch protein in ELISA, IHC, WB. Suitable for Human. Highlights Affinity Purified — Minimal background and high purity for reliable results. Multi-Application — Validated across multiple applications.
种属反应性	Human
应用	ELISA, IHC, WB
宿主	Rabbit
克隆类型	Polyclonal
同种型	IgG
免疫原	E. coli - derived recombinant Human CHAC1 (Gln31-Val222).
靶标	Glutathione-specific gamma-glutamylcyclotransferase 1, Gamma-GCG 1, Cation transport regulator-like protein 1, CHAC1, Botch, BOTCH, Blocks Notch protein
纯化方式	Purified by antigen affinity column.
Accession号	Q9BUX1
状态	Liquid
保存溶液	0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景	Glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1/Botch) is a ~24 kDa protein. Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. Glutathione depletion is an important factor for apoptosis initiation and execution. Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade. Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos. 1. Kaur, A. et al. (2017) The Journal of biological chemistry 292, 638-651. PMID: 27913623 2. Mungrue, IN. et al. (2009) Journal of immunology (Baltimore, Md. : 1950) 182, 466-76. PMID: 19109178 3. Chi, Z. et al. (2012) Developmental cell 22, 707-20. PMID: 22445366
Note	For research use only.

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参考文献

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公式

C₁ × V₁ = C₂ × V₂

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母液

C₁ (起始浓度)

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V₁ (起始体积)

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工作液

C₂ (终浓度)

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V₂ (终体积)

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Anti-Human CHAC1 Polyclonal Antibody

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