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Anti-Human USP22 Polyclonal Antibody (ARO-A11864)

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概述
货号ARO-A11864
品牌ProteoGenix
描述
Anti-Human USP22 Polyclonal Antibody (ARO-A11864) is a rabbit polyclonal antibody detecting Deubiquitinating enzyme 22, USP22, Ubiquitin thioesterase 22, Ubiquitin carboxyl-terminal hydrolase 22, KIAA1063, USP3L, Ubiquitin-specific-processing protease 22 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human USP22 (Gly182-Glu525).
靶标Deubiquitinating enzyme 22, USP22, Ubiquitin thioesterase 22, Ubiquitin carboxyl-terminal hydrolase 22, KIAA1063, USP3L, Ubiquitin-specific-processing protease 22
纯化方式Purified by antigen affinity column.
Accession号Q9UPT9
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Ubiquitin carboxyl-terminal hydrolase 22 (USP22) is a ~59 kDa protein. Deubiquitinase that plays a role in several cellular processes including transcriptional regulation, cell cycle progression or innate immunity. As part of the transcription regulatory histone acetylation (HAT) complex SAGA, catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a transcriptional coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Facilitates cell-cycle progression by stabilizing CCNB1 and antagonizing its proteasome-mediated degradation in a cell cycle-specific manner. Modulates cell cycle progression and apoptosis also by antagonizing TP53 transcriptional activation through deacetylase SIRT1 stabilization.

1. Zhao, Y. et al. (2008) Molecular cell 29, 92-101. PMID: 18206972
2. Zhang, XY. et al. (2008) Molecular cell 29, 102-11. PMID: 18206973
3. Zhang, XY. et al. (2008) Cell cycle (Georgetown, Tex.) 7, 1522-4. PMID: 18469533
4. Lin, Z. et al. (2015) Cell discovery 1, 15028-. PMID: 27030811
5. Lin, Z. et al. (2012) Molecular cell 46, 484-94. PMID: 22542455
6. Cai, Z. et al. (2020) The Journal of experimental medicine 217. PMID: 32130408
7. Karlowitz, R. et al. (2022) Cell death & disease 13, 684. PMID: 35933402
8. Huang, X. et al. (2019) Cancer immunology research 7, 1580-1590. PMID: 31399419
9. Roedig, J. et al. (2021) EMBO reports 22, e50163. PMID: 33369872
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-Human USP22 Polyclonal Antibody

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