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Anti-Human TRIM14 Polyclonal Antibody (ARO-A11873)

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概述
货号ARO-A11873
品牌ProteoGenix
描述
Anti-Human TRIM14 Polyclonal Antibody (ARO-A11873) is a rabbit polyclonal antibody detecting KIAA0129, Tripartite motif-containing protein 14, TRIM14 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human TRIM14 (Ser254-Pro442).
靶标KIAA0129, Tripartite motif-containing protein 14, TRIM14
纯化方式Purified by antigen affinity column.
Accession号Q14142
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Tripartite motif-containing protein 14 (TRIM14) is a ~49 kDa protein. Plays an essential role in the innate immune defense against viruses and bacteria. Promotes the 'Lys-48'-linked ubiquitination and subsequent degradation of hepatitis C virus NS5A leading to the inhibition of viral replication. Also plays a role in the inhibition of ebolavirus infection by enhancing IFN-beta and NF-kappa-B activation after binding to the viral protein NP. Facilitates the type I IFN response by interacting with MAVS at the outer mitochondria membrane and thereby recruiting NF-kappa-B essential modulator IKBKG/NEMO to the MAVS signalosome, leading to the activation of both the IFN regulatory factor 3/IRF3 and NF-kappa-B pathways. Positively regulates the CGAS-induced type I interferon signaling pathway by stabilizing CGAS and inhibiting its autophagic degradation.

1. Tan, G. et al. (2018) Frontiers in immunology 9, 1872. PMID: 30150992
2. Hoffpauir, CT. et al. (2020) Journal of immunology (Baltimore, Md. : 1950) 205, 153-167. PMID: 32404352
3. Wang, S. et al. (2016) Scientific reports 6, 32336. PMID: 27578425
4. Kuroda, M. et al. (2023) The Journal of infectious diseases 228, S514-S521. PMID: 37562033
5. Zhou, Z. et al. (2014) Proceedings of the National Academy of Sciences of the United States of America 111, E245-54. PMID: 24379373
6. Chen, M. et al. (2016) Molecular cell 64, 105-119. PMID: 27666593
7. Liu, D. et al. (2022) Proceedings of the National Academy of Sciences of the United States of America 119. PMID: 35145029
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-Human TRIM14 Polyclonal Antibody

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