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Anti-Human WDR24 Polyclonal Antibody (ARO-A11823)

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概述
货号ARO-A11823
品牌ProteoGenix
描述
Anti-Human WDR24 Polyclonal Antibody (ARO-A11823) is a rabbit polyclonal antibody detecting WDR24, C16orf21, GATOR complex protein WDR24, WD repeat-containing protein 24 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human WDR24 (Glu57-Thr158).
靶标WDR24, C16orf21, GATOR complex protein WDR24, WD repeat-containing protein 24
纯化方式Purified by antigen affinity column.
Accession号Q96S15
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

GATOR2 complex protein WDR24 is a ~88 kDa protein. Catalytic component of the GATOR2 complex, a multiprotein complex that acts as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway. The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex. GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1. In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation. In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex.

1. Bar-Peled, L. et al. (2013) Science (New York, N.Y.) 340, 1100-6. PMID: 23723238
2. Wolfson, RL. et al. (2016) Science (New York, N.Y.) 351, 43-8. PMID: 26449471
3. Saxton, RA. et al. (2016) Science (New York, N.Y.) 351, 53-8. PMID: 26586190
4. Saxton, RA. et al. (2016) Nature 536, 229-33. PMID: 27487210
5. Valenstein, ML. et al. (2022) Nature 607, 610-616. PMID: 35831510
6. Jiang, C. et al. (2023) Molecular cell 83, 74-89.e9. PMID: 36528027
7. Dai, X. et al. (2023) Nature metabolism 5, 265-276. PMID: 36732624
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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