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Anti-Human GET3 Polyclonal Antibody (ARO-A11830)

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概述
货号ARO-A11830
品牌ProteoGenix
描述
Anti-Human GET3 Polyclonal Antibody (ARO-A11830) is a rabbit polyclonal antibody detecting Arsenite-stimulated ATPase, TRC40, ATPase GET3, hASNA-I, Arsenical pump-driving ATPase, hARSA-I, GET3, ARSA, ASNA1, Guided entry of tail-anchored proteins factor 3, ATPase, Transmembrane domain recognition complex 40 kDa ATPase subunit in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human GET3 (Ser36-Gln348).
靶标Arsenite-stimulated ATPase, TRC40, ATPase GET3, hASNA-I, Arsenical pump-driving ATPase, hARSA-I, GET3, ARSA, ASNA1, Guided entry of tail-anchored proteins factor 3, ATPase, Transmembrane domain recognition complex 40 kDa ATPase subunit
纯化方式Purified by antigen affinity column.
Accession号O43681
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

ATPase GET3 is a ~38 kDa protein. ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors GET1/WRB and CAMLG/GET2, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins.

1. Stefanovic, S. et al. (2007) Cell 128, 1147-59. PMID: 17382883
NoteFor research use only.
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参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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