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Anti-Human BHLHE41 Polyclonal Antibody (ARO-A11806)

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概述
货号ARO-A11806
品牌ProteoGenix
描述
Anti-Human BHLHE41 Polyclonal Antibody (ARO-A11806) is a rabbit polyclonal antibody detecting bHLHe41, hDEC2, DEC2, bHLHb3, Enhancer-of-split and hairy-related protein 1, Class E basic helix-loop-helix protein 41, Class B basic helix-loop-helix protein 3, BHLHB3, SHARP1, SHARP-1, Differentially expressed in chondrocytes protein 2, BHLHE41 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human BHLHE41 (Asp40-Leu174).
靶标bHLHe41, hDEC2, DEC2, bHLHb3, Enhancer-of-split and hairy-related protein 1, Class E basic helix-loop-helix protein 41, Class B basic helix-loop-helix protein 3, BHLHB3, SHARP1, SHARP-1, Differentially expressed in chondrocytes protein 2, BHLHE41
纯化方式Purified by antigen affinity column.
Accession号Q9C0J9
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Class E basic helix-loop-helix protein 41 (BHLHE41) is a ~50 kDa protein. Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-BMAL1 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2.

1. Garriga-Canut, M. et al. (2001) The Journal of biological chemistry 276, 14821-8. PMID: 11278948
2. Kawamoto, T. et al. (2004) Biochemical and biophysical research communications 313, 117-24. PMID: 14672706
3. Li, Y. et al. (2004) The Biochemical journal 382, 895-904. PMID: 15193144
4. Sato, F. et al. (2004) European journal of biochemistry 271, 4409-19. PMID: 15560782
5. Nakashima, A. et al. (2008) Molecular and cellular biology 28, 4080-92. PMID: 18411297
6. Cho, Y. et al. (2009) Molecular pharmacology 76, 1360-9. PMID: 19786558
7. Pellegrino, R. et al. (2014) Sleep 37, 1327-36. PMID: 25083013
NoteFor research use only.
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参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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