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Anti-Human USP20 Polyclonal Antibody (ARO-A11865)

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概述
货号ARO-A11865
品牌ProteoGenix
描述
Anti-Human USP20 Polyclonal Antibody (ARO-A11865) is a rabbit polyclonal antibody detecting LSFR3A, Ubiquitin carboxyl-terminal hydrolase 20, KIAA1003, Ubiquitin-specific-processing protease 20, VHL-interacting deubiquitinating enzyme 2, Ubiquitin thioesterase 20, VDU2, hVDU2, Deubiquitinating enzyme 20, USP20 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human USP20 (Ser781-Val914).
靶标LSFR3A, Ubiquitin carboxyl-terminal hydrolase 20, KIAA1003, Ubiquitin-specific-processing protease 20, VHL-interacting deubiquitinating enzyme 2, Ubiquitin thioesterase 20, VDU2, hVDU2, Deubiquitinating enzyme 20, USP20
纯化方式Purified by antigen affinity column.
Accession号Q9Y2K6
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Ubiquitin carboxyl-terminal hydrolase 20 (USP20) is a ~102 kDa protein. Deubiquitinating enzyme that plays a role in many cellular processes including autophagy, cellular antiviral response or membrane protein biogenesis. Attenuates TLR4-mediated NF-kappa-B signaling by cooperating with beta-arrestin-2/ARRB2 and inhibiting TRAF6 autoubiquitination. Promotes cellular antiviral responses by deconjugating 'Lys-33' and 'Lys-48'-linked ubiquitination of STING1 leading to its stabilization. Plays an essential role in autophagy induction by regulating the ULK1 stability through deubiquitination of ULK1. Acts as a positive regulator for NF-kappa-B activation by TNF through deubiquitinating 'Lys-48'-linked polyubiquitination of SQSTM1, leading to its increased stability.

1. Zhang, M. et al. (2016) Cell research 26, 1302-1319. PMID: 27801882
2. Kim, JH. et al. (2018) EMBO reports 19. PMID: 29487085
3. Jean-Charles, PY. et al. (2016) The Journal of biological chemistry 291, 7450-64. PMID: 26839314
4. Ha, J. et al. (2020) International journal of molecular sciences 21. PMID: 32354117
5. Berthouze, M. et al. (2009) The EMBO journal 28, 1684-96. PMID: 19424180
6. Li, Z. et al. (2005) EMBO reports 6, 373-8. PMID: 15776016
7. Feng, J. et al. (2022) Biochemical and biophysical research communications 593, 122-128. PMID: 35063767
NoteFor research use only.
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参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-Human USP20 Polyclonal Antibody

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