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Anti-Human ARPP19 Polyclonal Antibody (ARO-A11904)

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概述
货号ARO-A11904
品牌ProteoGenix
描述
Anti-Human ARPP19 Polyclonal Antibody (ARO-A11904) is a rabbit polyclonal antibody detecting cAMP-regulated phosphoprotein 19, ARPP19, ARPP-19 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human ARPP19 (Ser2-Leu77).
靶标cAMP-regulated phosphoprotein 19, ARPP19, ARPP-19
纯化方式Purified by antigen affinity column.
Accession号P56211
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

cAMP-regulated phosphoprotein 19 (ARPP19) is a ~12 kDa protein. Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. Inhibition of PP2A is enhanced when ARPP19 is phosphorylated. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression.

1. Padi, SKR. et al. (2024) Nature 625, 195-203. PMID: 38123684
2. Gharbi-Ayachi, A. et al. (2010) Science (New York, N.Y.) 330, 1673-7. PMID: 21164014
NoteFor research use only.
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参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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