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Anti-Human PRKRA Polyclonal Antibody (ARO-A11973)

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概述
货号ARO-A11973
品牌ProteoGenix
描述
Anti-Human PRKRA Polyclonal Antibody (ARO-A11973) is a rabbit polyclonal antibody detecting PKR-associated protein X, Protein activator of the interferon-induced protein kinase, PACT, PRKRA, RAX, PKR-associating protein X, Interferon-inducible double-stranded RNA-dependent protein kinase activator A, Protein kinase, interferon-inducible double-stranded RNA-dependent activator in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human PRKRA (Asn126-Lys313).
靶标PKR-associated protein X, Protein activator of the interferon-induced protein kinase, PACT, PRKRA, RAX, PKR-associating protein X, Interferon-inducible double-stranded RNA-dependent protein kinase activator A, Protein kinase, interferon-inducible double-stranded RNA-dependent activator
纯化方式Purified by antigen affinity column.
Accession号O75569
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Interferon-inducible double-stranded RNA-dependent protein kinase activator A (PRKRA) is a ~34 kDa protein. Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner. May function as regulator of gastric epithelial differentiation.

NoteFor research use only.
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参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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