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Anti-Human USP3 Polyclonal Antibody (ARO-A12033)

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概述
货号ARO-A12033
品牌ProteoGenix
描述
Anti-Human USP3 Polyclonal Antibody (ARO-A12033) is a rabbit polyclonal antibody detecting Deubiquitinating enzyme 3, Ubiquitin thioesterase 3, USP3, Ubiquitin-specific-processing protease 3, Ubiquitin carboxyl-terminal hydrolase 3 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human USP3 (Gly316-Leu520).
靶标Deubiquitinating enzyme 3, Ubiquitin thioesterase 3, USP3, Ubiquitin-specific-processing protease 3, Ubiquitin carboxyl-terminal hydrolase 3
纯化方式Purified by antigen affinity column.
Accession号Q9Y6I4
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Ubiquitin carboxyl-terminal hydrolase 3 (USP3) is a ~58 kDa protein. Deubiquitinase that plays a role in several cellular processes including transcriptional regulation, cell cycle progression or innate immunity. In response to DNA damage, deubiquitinates monoubiquitinated target proteins such as histone H2A and H2AX and thereby counteracts RNF168- and RNF8-mediated ubiquitination. In turn, participates in the recruitment of DNA damage repair factors to DNA break sites. Required for proper progression through S phase and subsequent mitotic entry. Acts as a positive regulator of TP53 by deubiquitinating and stabilizing it to promote normal cell proliferation and transformation.

1. Sharma, N. et al. (2014) Cell cycle (Georgetown, Tex.) 13, 106-14. PMID: 24196443
2. Nicassio, F. et al. (2007) Current biology : CB 17, 1972-7. PMID: 17980597
3. Fu, S. et al. (2017) Biochemical and biophysical research communications 492, 178-183. PMID: 28807825
4. Duan, T. et al. (2023) EMBO reports 24, e57828. PMID: 37971847
5. Cui, J. et al. (2014) Cell research 24, 400-16. PMID: 24366338
6. Zhuang, W. et al. (2022) Cellular & molecular immunology 19, 1141-1152. PMID: 36050480
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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