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Anti-Human MCM7 Polyclonal Antibody (ARO-A12007)

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概述
货号ARO-A12007
品牌ProteoGenix
描述
Anti-Human MCM7 Polyclonal Antibody (ARO-A12007) is a rabbit polyclonal antibody detecting DNA replication licensing factor MCM7, MCM2, P1.1-MCM3, CDC47 homolog, MCM7, CDC47 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human MCM7 (Met1-Lys305).
靶标DNA replication licensing factor MCM7, MCM2, P1.1-MCM3, CDC47 homolog, MCM7, CDC47
纯化方式Purified by antigen affinity column.
Accession号P33993
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

DNA replication licensing factor MCM7 is a ~81 kDa protein. Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for S-phase checkpoint activation upon UV-induced damage.

1. Ishimi, Y. et al. (2015) Journal of biochemistry 157, 561-9. PMID: 25661590
2. Rzechorzek, NJ. et al. (2020) Nucleic acids research 48, 6980-6995. PMID: 32453425
3. Jones, ML. et al. (2021) The EMBO journal 40, e108819. PMID: 34694004
4. Jenkyn-Bedford, M. et al. (2021) Nature 600, 743-747. PMID: 34700328
5. Baris, Y. et al. (2022) Nature 606, 204-210. PMID: 35585232
6. Ishimi, Y. (1997) The Journal of biological chemistry 272, 24508-13. PMID: 9305914
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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