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Anti-Human SELENON Polyclonal Antibody (ARO-A11989)

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概述
货号ARO-A11989
品牌ProteoGenix
描述
Anti-Human SELENON Polyclonal Antibody (ARO-A11989) is a rabbit polyclonal antibody detecting SelN, Selenoprotein N, SELENON, SELN, SEPN1 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human SELENON (Ser464-Pro590).
靶标SelN, Selenoprotein N, SELENON, SELN, SEPN1
纯化方式Purified by antigen affinity column.
Accession号Q9NZV5
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Selenoprotein N (SELENON) is a ~65 kDa protein. Plays an important role in cell protection against oxidative stress and in the regulation of redox-related calcium homeostasis. Regulates the calcium level of the ER by protecting the calcium pump ATP2A2 against the oxidoreductase ERO1A-mediated oxidative damage. Within the ER, ERO1A activity increases the concentration of H(2)O(2), which attacks the luminal thiols in ATP2A2 and thus leads to cysteinyl sulfenic acid formation (-SOH) and SEPN1 reduces the SOH back to free thiol (-SH), thus restoring ATP2A2 activity. Acts as a modulator of ryanodine receptor (RyR) activity: protects RyR from oxidation due to increased oxidative stress, or directly controls the RyR redox state, regulating the RyR-mediated calcium mobilization required for normal muscle development and differentiation.

1. Marino, M. et al. (2015) Human molecular genetics 24, 1843-55. PMID: 25452428
2. Jurynec, MJ. et al. (2008) Proceedings of the National Academy of Sciences of the United States of America 105, 12485-90. PMID: 18713863
3. Arbogast, S. et al. (2009) Annals of neurology 65, 677-86. PMID: 19557870
NoteFor research use only.
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参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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