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Anti-Human PPP1CB Polyclonal Antibody (ARO-A12073)

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概述
货号ARO-A12073
品牌ProteoGenix
描述
Anti-Human PPP1CB Polyclonal Antibody (ARO-A12073) is a rabbit polyclonal antibody detecting Serine/threonine-protein phosphatase PP1-beta catalytic subunit, PPP1CD, PP-1B, PPP1CB in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human PPP1CB (Met1-Arg327).
靶标Serine/threonine-protein phosphatase PP1-beta catalytic subunit, PPP1CD, PP-1B, PPP1CB
纯化方式Purified by antigen affinity column.
Accession号P62140
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PPP1CB) is a ~37 kDa protein. Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation.

1. Nie, H. et al. (2013) Nature medicine 19, 322-8. PMID: 23396208
2. Liau, NPD. et al. (2022) Nature 609, 400-407. PMID: 35768504
3. Kwon, JJ. et al. (2022) Nature 609, 408-415. PMID: 35831509
4. Bonsor, DA. et al. (2022) Nature structural & molecular biology 29, 966-977. PMID: 36175670
NoteFor research use only.
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参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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