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Anti-Human EWSR1 Polyclonal Antibody (ARO-A12109)

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概述
货号ARO-A12109
品牌ProteoGenix
描述
Anti-Human EWSR1 Polyclonal Antibody (ARO-A12109) is a rabbit polyclonal antibody detecting RNA-binding protein EWS, EWS oncogene, EWS, EWSR1, Ewing sarcoma breakpoint region 1 protein in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human EWSR1 (Asp353-Arg446).
靶标RNA-binding protein EWS, EWS oncogene, EWS, EWSR1, Ewing sarcoma breakpoint region 1 protein
纯化方式Purified by antigen affinity column.
Accession号Q01844
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

RNA-binding protein EWS (EWSR1) is a ~68 kDa protein. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3'. Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

1. Nguyen, CD. et al. (2011) Journal of molecular biology 407, 273-83. PMID: 21256132
2. Li, KK. et al. (2000) The Journal of biological chemistry 275, 23053-8. PMID: 10767297
NoteFor research use only.
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参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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