Forkhead box protein C1 (FOXC1) is a ~56 kDa protein. DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as eye, bones, cardiovascular, kidney and skin development. Acts either as a transcriptional activator or repressor. Binds to the consensus binding site 5'-[G/C][A/T]AAA[T/C]AA[A/C]-3' in promoter of target genes. Upon DNA-binding, promotes DNA bending. Acts as a transcriptional coactivator. 1. Berry, FB. et al. (2002) The Journal of biological chemistry 277, 10292-7. PMID: 117824742. Saleem, RA. et al. (2003) Human molecular genetics 12, 2993-3005. PMID: 145061333. Saleem, RA. et al. (2003) Investigative ophthalmology & visual science 44, 4608-12. PMID: 145783754. Murphy, TC. et al. (2004) Investigative ophthalmology & visual science 45, 2531-8. PMID: 152774735. Saleem, RA. et al. (2004) Nucleic acids research 32, 4182-93. PMID: 152990876. Berry, FB. et al. (2005) Molecular and cellular biology 25, 1415-24. PMID: 156843927. Berry, FB. et al. (2006) Human molecular genetics 15, 905-19. PMID: 164492368. Berry, FB. et al. (2006) The Journal of biological chemistry 281, 10098-104. PMID: 164926749. Ito, YA. et al. (2007) Archives of ophthalmology (Chicago, Ill. : 1960) 125, 128-35. PMID: 1721086310. Ito, YA. et al. (2009) Investigative ophthalmology & visual science 50, 3573-9. PMID: 19279310 | 
