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Anti-Human TNFAIP6 Polyclonal Antibody (ARO-A12138)

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概述
货号ARO-A12138
品牌ProteoGenix
描述
Anti-Human TNFAIP6 Polyclonal Antibody (ARO-A12138) is a rabbit polyclonal antibody detecting TNF alpha-induced protein 6, TNF-stimulated gene 6 protein, Tumor necrosis factor alpha-induced protein 6, Hyaluronate-binding protein, TSG6, Tumor necrosis factor-inducible gene 6 protein, TNFAIP6, TSG-6 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human TNFAIP6 (His26-Asp248).
靶标TNF alpha-induced protein 6, TNF-stimulated gene 6 protein, Tumor necrosis factor alpha-induced protein 6, Hyaluronate-binding protein, TSG6, Tumor necrosis factor-inducible gene 6 protein, TNFAIP6, TSG-6
纯化方式Purified by antigen affinity column.
Accession号P98066
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Tumor necrosis factor-inducible gene 6 protein (TNFAIP6/TSG-6) is a ~31 kDa protein. Major regulator of extracellular matrix organization during tissue remodeling. Catalyzes the transfer of a heavy chain (HC) from inter-alpha-inhibitor (I-alpha-I) complex to hyaluronan. Cleaves the ester bond between the C-terminus of the HC and GalNAc residue of the chondroitin sulfate chain in I-alpha-I complex followed by transesterification of the HC to hyaluronan. In the process, potentiates the antiprotease function of I-alpha-I complex through release of free bikunin. Acts as a catalyst in the formation of hyaluronan-HC oligomers and hyaluronan-rich matrix surrounding the cumulus cell-oocyte complex, a necessary step for oocyte fertilization.

1. Mahoney, DJ. et al. (2005) The Journal of biological chemistry 280, 27044-55. PMID: 15917224
2. Kuznetsova, SA. et al. (2008) Matrix biology : journal of the International Society for Matrix Biology 27, 201-10. PMID: 18042364
3. Lawrance, W. et al. (2016) The Journal of biological chemistry 291, 8014-30. PMID: 26823460
4. Forteza, R. et al. (2007) American journal of respiratory cell and molecular biology 36, 20-31. PMID: 16873769
5. Sanggaard, KW. et al. (2010) The Journal of biological chemistry 285, 21988-93. PMID: 20463016
6. Briggs, DC. et al. (2015) The Journal of biological chemistry 290, 28708-23. PMID: 26468290
7. Lesley, J. et al. (2004) The Journal of biological chemistry 279, 25745-54. PMID: 15060082
8. Dyer, DP. et al. (2016) The Journal of biological chemistry 291, 12627-12640. PMID: 27044744
10. Tsukahara, S. et al. (2006) The Biochemical journal 398, 595-603. PMID: 16771708
NoteFor research use only.
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参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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