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Anti-Human TRAIP Polyclonal Antibody (ARO-A12142)

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概述
货号ARO-A12142
品牌ProteoGenix
描述
Anti-Human TRAIP Polyclonal Antibody (ARO-A12142) is a rabbit polyclonal antibody detecting TRIP, RING finger protein 206, RNF206, TRAF-interacting protein, E3 ubiquitin-protein ligase TRAIP, TRAIP in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human TRAIP (Pro2-Asp75).
靶标TRIP, RING finger protein 206, RNF206, TRAF-interacting protein, E3 ubiquitin-protein ligase TRAIP, TRAIP
纯化方式Purified by antigen affinity column.
Accession号Q9BWF2
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

E3 ubiquitin-protein ligase TRAIP is a ~53 kDa protein. E3 ubiquitin ligase required to protect genome stability in response to replication stress. Acts as a key regulator of interstrand cross-link repair, which takes place when both strands of duplex DNA are covalently tethered together, thereby blocking replication and transcription. Controls the choice between the two pathways of replication-coupled interstrand-cross-link repair by mediating ubiquitination of MCM7 subunit of the CMG helicase complex. Short ubiquitin chains on MCM7 promote recruitment of DNA glycosylase NEIL3. If the interstrand cross-link cannot be cleaved by NEIL3, the ubiquitin chains continue to grow on MCM7, promoting the unloading of the CMG helicase complex by the VCP/p97 ATPase, enabling the Fanconi anemia DNA repair pathway.

1. Chapard, C. et al. (2014) Journal of cell science 127, 5149-56. PMID: 25335891
2. Harley, ME. et al. (2016) Nature genetics 48, 36-43. PMID: 26595769
3. Hoffmann, S. et al. (2016) The Journal of cell biology 212, 63-75. PMID: 26711499
4. Soo Lee, N. et al. (2016) Nature communications 7, 10463. PMID: 26781088
5. Feng, W. et al. (2016) Cell discovery 2, 16016. PMID: 27462463
6. Sonneville, R. et al. (2019) eLife 8. PMID: 31545170
7. Wallace, HA. et al. (2014) Development (Cambridge, England) 141, 1332-41. PMID: 24553286
8. Zhang, M. et al. (2012) The Journal of experimental medicine 209, 1703-11. PMID: 22945920
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-Human TRAIP Polyclonal Antibody

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