首页 > 产品中心 > 抗体 > 一抗

Anti-Human TFE3 Polyclonal Antibody (ARO-A12238)

概述
图片
参考文献

概述

货号	ARO-A12238
品牌	ProteoGenix
描述	Anti-Human TFE3 Polyclonal Antibody (ARO-A12238) is a rabbit polyclonal antibody detecting TFE3, bHLHe33, BHLHE33, Transcription factor E3, Class E basic helix-loop-helix protein 33 in ELISA, IHC, WB. Suitable for Human. Highlights Affinity Purified — Minimal background and high purity for reliable results. Multi-Application — Validated across multiple applications.
种属反应性	Human
应用	ELISA, IHC, WB
宿主	Rabbit
克隆类型	Polyclonal
同种型	IgG
免疫原	E. coli - derived recombinant Human TFE3 (Asn185-Ser281).
靶标	TFE3, bHLHe33, BHLHE33, Transcription factor E3, Class E basic helix-loop-helix protein 33
纯化方式	Purified by antigen affinity column.
Accession号	P19532
状态	Liquid
保存溶液	0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景	Transcription factor E3 (TFE3) is a ~61 kDa protein. Transcription factor that acts as a master regulator of lysosomal biogenesis and immune response. Specifically recognizes and binds E-box sequences (5'-CANNTG-3'); efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF. Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, TFE3 phosphorylation by MTOR promotes its inactivation. Upon starvation or lysosomal stress, inhibition of MTOR induces TFE3 dephosphorylation, resulting in transcription factor activity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression, thereby playing a central role in expression of lysosomal genes. 1. Beckmann, H. et al. (1990) Genes & development 4, 167-79. PMID: 2338243 2. Martina, JA. et al. (2014) Science signaling 7, ra9. PMID: 24448649 3. Willett, R. et al. (2017) Nature communications 8, 1580. PMID: 29146937 4. Mathieu, J. et al. (2019) Nature communications 10, 632. PMID: 30733432 5. Lawrence, RE. et al. (2019) Science (New York, N.Y.) 366, 971-977. PMID: 31672913 6. Malik, N. et al. (2023) Science (New York, N.Y.) 380, eabj5559. PMID: 37079666 7. Nardone, C. et al. (2023) Molecular cell 83, 57-73.e9. PMID: 36608670
Note	For research use only.

图片

参考文献

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

=

浓度

×

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

×

V₁ (起始体积)

=

工作液

C₂ (终浓度)

×

V₂ (终体积)

相关产品推荐

Anti-Human TFE3 Polyclonal Antibody

7X24小时产品咨询热线：027--87433958(9:00-18:00)，或扫描下方产品专员二维码或在线留言
武汉东湖新技术开发区神墩四路666号研发楼B区3层东

24小时产品查询
扫一扫关注我们
专属渠道经理

Copyright © 2026 武汉艾必赛生物科技有限公司版权所有所有产品仅可用于工业或者科研等非医疗目的。

鄂ICP备2023002448号-2