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Anti-Human WDR45 Polyclonal Antibody (ARO-A12236)

概述
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概述

货号	ARO-A12236
品牌	ProteoGenix
描述	Anti-Human WDR45 Polyclonal Antibody (ARO-A12236) is a rabbit polyclonal antibody detecting WD repeat-containing protein 45, WD repeat domain phosphoinositide-interacting protein 4, WDR45, WDRX1, WDRXI4, WIPI-4, WIPI4 in ELISA, IHC, WB. Suitable for Human. Highlights Affinity Purified — Minimal background and high purity for reliable results. Multi-Application — Validated across multiple applications.
种属反应性	Human
应用	ELISA, IHC, WB
宿主	Rabbit
克隆类型	Polyclonal
同种型	IgG
免疫原	E. coli - derived recombinant Human WDR45 (Cys23-Ala184).
靶标	WD repeat-containing protein 45, WD repeat domain phosphoinositide-interacting protein 4, WDR45, WDRX1, WDRXI4, WIPI-4, WIPI4
纯化方式	Purified by antigen affinity column.
Accession号	Q9Y484
状态	Liquid
保存溶液	0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景	WD repeat domain phosphoinositide-interacting protein 4 (WDR45) is a ~39 kDa protein. Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. Binds phosphatidylinositol 3-phosphate (PtdIns3P). Activated by the STK11/AMPK signaling pathway upon starvation, WDR45 is involved in autophagosome assembly downstream of WIPI2, regulating the size of forming autophagosomes. Together with WIPI1, promotes ATG2 (ATG2A or ATG2B)-mediated lipid transfer by enhancing ATG2-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes. Probably recruited to membranes through its PtdIns3P activity. 1. Saitsu, H. et al. (2013) Nature genetics 45, 445-9, 449e1. PMID: 23435086 2. Bakula, D. et al. (2017) Nature communications 8, 15637. PMID: 28561066 3. Maeda, S. et al. (2019) eLife 8. PMID: 31271352
Note	For research use only.

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参考文献

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公式

C₁ × V₁ = C₂ × V₂

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母液

C₁ (起始浓度)

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V₁ (起始体积)

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C₂ (终浓度)

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V₂ (终体积)

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Anti-Human WDR45 Polyclonal Antibody

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