

| 货号 | ARO-A12201 |
|---|---|
| 品牌 | ProteoGenix |
| 描述 |
Anti-Human TRIM16 Polyclonal Antibody (ARO-A12201) is a rabbit polyclonal antibody detecting Estrogen-responsive B box protein, Tripartite motif-containing protein 16, TRIM16, EBBP, E3 ubiquitin-protein ligase TRIM16 in ELISA, IHC, WB. Suitable for Human.
Highlights
|
| 种属反应性 | Human |
| 应用 | ELISA, IHC, WB |
| 宿主 | Rabbit |
| 克隆类型 | Polyclonal |
| 同种型 | IgG |
| 免疫原 | E. coli - derived recombinant Human TRIM16 (Lys384-Pro564). |
| 靶标 | Estrogen-responsive B box protein, Tripartite motif-containing protein 16, TRIM16, EBBP, E3 ubiquitin-protein ligase TRIM16 |
| 纯化方式 | Purified by antigen affinity column. |
| Accession号 | O95361 |
| 状态 | Liquid |
| 保存溶液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 背景 | Tripartite motif-containing protein 16 (TRIM16) is a ~63 kDa protein. E3 ubiquitin ligase that plays an essential role in the organization of autophagic response and ubiquitination upon lysosomal and phagosomal damages. Plays a role in the stress-induced biogenesis and degradation of protein aggresomes by regulating the p62-KEAP1-NRF2 signaling and particularly by modulating the ubiquitination levels and thus stability of NRF2. Acts as a scaffold protein and facilitates autophagic degradation of protein aggregates by interacting with p62/SQSTM, ATG16L1 and LC3B/MAP1LC3B. In turn, protects the cell against oxidative stress-induced cell death as a consequence of endomembrane damage. |
| Note | For research use only. |

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