Non-homologous end-joining factor 1 (NHEJ1) is a ~33 kDa protein. DNA repair protein involved in DNA non-homologous end joining (NHEJ); it is required for double-strand break (DSB) repair and V(D)J recombination and is also involved in telomere maintenance. Plays a key role in NHEJ by promoting the ligation of various mismatched and non-cohesive ends. Together with PAXX, collaborates with DNA polymerase lambda (POLL) to promote joining of non-cohesive DNA ends. May act in concert with XRCC5-XRCC6 (Ku) to stimulate XRCC4-mediated joining of blunt ends and several types of mismatched ends that are non-complementary or partially complementary. In some studies, has been shown to associate with XRCC4 to form alternating helical filaments that bridge DNA and act like a bandage, holding together the broken DNA until it is repaired. 3. Lu, H. et al. (2007) The Journal of biological chemistry 282, 11155-62. PMID: 173176664. Tsai, CJ. et al. (2007) Proceedings of the National Academy of Sciences of the United States of America 104, 7851-6. PMID: 174707815. Gu, J. et al. (2007) Nucleic acids research 35, 5755-62. PMID: 177170016. Andres, SN. et al. (2007) Molecular cell 28, 1093-101. PMID: 181589058. Malivert, L. et al. (2010) The Journal of biological chemistry 285, 26475-83. PMID: 205587499. Roy, S. et al. (2015) Molecular and cellular biology 35, 3017-28. PMID: 2610001810. Carrillo, J. et al. (2017) Human molecular genetics 26, 1900-1914. PMID: 28369633 | 
