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Anti-Human FA2H Polyclonal Antibody (ARO-A12280)

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概述
货号ARO-A12280
品牌ProteoGenix
描述
Anti-Human FA2H Polyclonal Antibody (ARO-A12280) is a rabbit polyclonal antibody detecting Fatty acid 2-hydroxylase, Fatty acid alpha-hydroxylase, FAXDC1, FAAH, FA2H, Fatty acid hydroxylase domain-containing protein 1 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human FA2H (Ser12-Arg86).
靶标Fatty acid 2-hydroxylase, Fatty acid alpha-hydroxylase, FAXDC1, FAAH, FA2H, Fatty acid hydroxylase domain-containing protein 1
纯化方式Purified by antigen affinity column.
Accession号Q7L5A8
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Fatty acid 2-hydroxylase (FA2H) is a ~42 kDa protein. Catalyzes the hydroxylation of free fatty acids at the C-2 position to produce 2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. FA2H is stereospecific for the production of (R)-2-hydroxy fatty acids. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters in sebaceous gland, specifically regulating hair follicle homeostasis.

1. Alderson, NL. et al. (2004) The Journal of biological chemistry 279, 48562-8. PMID: 15337768
2. Alderson, NL. et al. (2005) Journal of lipid research 46, 1569-75. PMID: 15863841
3. Uchida, Y. et al. (2007) The Journal of biological chemistry 282, 13211-9. PMID: 17355976
4. Guo, L. et al. (2012) Journal of lipid research 53, 1327-35. PMID: 22517924
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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