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Anti-Human VPS41 Polyclonal Antibody (ARO-A12270)

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概述
货号ARO-A12270
品牌ProteoGenix
描述
Anti-Human VPS41 Polyclonal Antibody (ARO-A12270) is a rabbit polyclonal antibody detecting Vacuolar protein sorting-associated protein 41 homolog, VPS41, S53 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human VPS41 (Lys31-Asp361).
靶标Vacuolar protein sorting-associated protein 41 homolog, VPS41, S53
纯化方式Purified by antigen affinity column.
Accession号P49754
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Vacuolar protein sorting-associated protein 41 homolog (VPS41) is a ~98 kDa protein. Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Acts as a component of the HOPS endosomal tethering complex. This complex is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. Involved in homotypic vesicle fusions between late endosomes and in heterotypic fusions between late endosomes and lysosomes implicated in degradation of endocytosed cargo.

1. Solinger, JA. et al. (2013) The FEBS journal 280, 2743-57. PMID: 23351085
2. van der Welle, REN. et al. (2021) EMBO molecular medicine 13, e13258. PMID: 33851776
3. Pols, MS. et al. (2013) Traffic (Copenhagen, Denmark) 14, 219-32. PMID: 23167963
4. Lin, X. et al. (2014) Scientific reports 4, 7282. PMID: 25445562
5. Khatter, D. et al. (2015) Journal of cell science 128, 1746-61. PMID: 25908847
6. Radisky, DC. et al. (1997) Proceedings of the National Academy of Sciences of the United States of America 94, 5662-6. PMID: 9159129
7. Wartosch, L. et al. (2015) Traffic (Copenhagen, Denmark) 16, 727-42. PMID: 25783203
8. Zhang, S. et al. (2023) Nature communications 14, 6360. PMID: 37821429
9. Garg, S. et al. (2011) Immunity 35, 182-93. PMID: 21802320
NoteFor research use only.
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参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-Human VPS41 Polyclonal Antibody

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