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Anti-Human TAX1BP1 Polyclonal Antibody (ARO-A12341)

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概述
货号ARO-A12341
品牌ProteoGenix
描述
Anti-Human TAX1BP1 Polyclonal Antibody (ARO-A12341) is a rabbit polyclonal antibody detecting Tax1-binding protein 1, TAX1BP1, TRAF6-binding protein, T6BP in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human TAX1BP1 (His16-Lys146).
靶标Tax1-binding protein 1, TAX1BP1, TRAF6-binding protein, T6BP
纯化方式Purified by antigen affinity column.
Accession号Q86VP1
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Tax1-binding protein 1 (TAX1BP1) is a ~90 kDa protein. Ubiquitin-binding adapter that participates in inflammatory, antiviral and innate immune processes as well as selective autophagy regulation. Plays a key role in the negative regulation of NF-kappa-B and IRF3 signalings by acting as an adapter for the ubiquitin-editing enzyme A20/TNFAIP3 to bind and inactivate its substrates. Disrupts the interactions between the E3 ubiquitin ligase TRAF3 and TBK1/IKBKE to attenuate 'Lys63'-linked polyubiquitination of TBK1 and thereby IFN-beta production. Also recruits A20/TNFAIP3 to ubiquitinated signaling proteins TRAF6 and RIPK1, leading to their deubiquitination and disruption of IL-1 and TNF-induced NF-kappa-B signaling pathways. Inhibits virus-induced apoptosis by inducing the 'Lys-48'-linked polyubiquitination and degradation of MAVS via recruitment of the E3 ligase ITCH, thereby attenuating MAVS-mediated apoptosis signaling.

1. Hu, S. et al. (2018) Journal of molecular biology 430, 3283-3296. PMID: 29940186
2. Fu, T. et al. (2018) Proceedings of the National Academy of Sciences of the United States of America 115, E11651-E11660. PMID: 30459273
3. Baillet, N. et al. (2019) Viruses 11. PMID: 30909570
4. Shembade, N. et al. (2007) The EMBO journal 26, 3910-22. PMID: 17703191
5. Gao, L. et al. (2011) The Journal of biological chemistry 286, 36592-602. PMID: 21885437
6. Choi, YB. et al. (2017) Molecular and cellular biology 37. PMID: 27736772
7. Tumbarello, DA. et al. (2015) PLoS pathogens 11, e1005174. PMID: 26451915
8. Ohnstad, AE. et al. (2020) The EMBO journal 39, e104948. PMID: 33226137
9. Turco, E. et al. (2021) Nature communications 12, 5212. PMID: 34471133
10. Yang, Q. et al. (2017) PLoS pathogens 13, e1006600. PMID: 28898289
NoteFor research use only.
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参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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