| 背景 | KH domain-containing RNA-binding protein QKI is a ~37 kDa protein. RNA reader protein, which recognizes and binds specific RNAs, thereby regulating RNA metabolic processes, such as pre-mRNA splicing, circular RNA (circRNA) formation, mRNA export, mRNA stability and/or translation. Involved in various cellular processes, such as mRNA storage into stress granules, apoptosis, lipid deposition, interferon response, glial cell fate and development. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts as a mRNA modification reader that specifically recognizes and binds mRNA transcripts modified by internal N(7)-methylguanine (m7G). Promotes the formation of circular RNAs (circRNAs) during the epithelial to mesenchymal transition and in cardiomyocytes: acts by binding to sites flanking circRNA-forming exons. 1. Fu, H. et al. (2012) Molecular biology of the cell 23, 1628-35. PMID: 223987232. Teplova, M. et al. (2013) Genes & development 27, 928-40. PMID: 236300774. de Bruin, RG. et al. (2016) Nature communications 7, 10846. PMID: 270294055. Caines, R. et al. (2019) Journal of cell science 132. PMID: 313319678. Liao, KC. et al. (2021) Nucleic acids research 49, 10034-10045. PMID: 34428287 |
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