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Anti-Human TRIM27 Polyclonal Antibody (ARO-A12411)

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概述
货号ARO-A12411
品牌ProteoGenix
描述
Anti-Human TRIM27 Polyclonal Antibody (ARO-A12411) is a rabbit polyclonal antibody detecting RING finger protein 76, Zinc finger protein RFP, RFP, TRIM27, RNF76, RING-type E3 ubiquitin transferase TRIM27, Tripartite motif-containing protein 27, Ret finger protein in ELISA, IHC, WB. Suitable for Human, Mouse.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human TRIM27 (Ser315-Pro513).
靶标RING finger protein 76, Zinc finger protein RFP, RFP, TRIM27, RNF76, RING-type E3 ubiquitin transferase TRIM27, Tripartite motif-containing protein 27, Ret finger protein
纯化方式Purified by antigen affinity column.
Accession号P14373
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Zinc finger protein RFP (TRIM27) is a ~58 kDa protein. E3 ubiquitin-protein ligase that mediates ubiquitination of various substrates and thereby plays a role in diffent processes including proliferation, innate immunity, apoptosis, immune response or autophagy. Ubiquitinates PIK3C2B and inhibits its activity by mediating the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T-cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1, leading to promote endosomal F-actin assembly. Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events.

1. Zurek, B. et al. (2012) PloS one 7, e41255. PMID: 22829933
2. Zaman, MM. et al. (2013) Molecular and cellular biology 33, 4971-84. PMID: 24144979
3. Cai, J. et al. (2018) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 32, 5238-5249. PMID: 29688809
4. Garcia-Garcia, J. et al. (2023) The FEBS journal 290, 1096-1116. PMID: 36111389
5. Hao, YH. et al. (2013) Cell 152, 1051-64. PMID: 23452853
6. Zheng, Q. et al. (2015) Cell research 25, 1121-36. PMID: 26358190
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-Human TRIM27 Polyclonal Antibody

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