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Anti-Human MCM6 Polyclonal Antibody (ARO-A12462)

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概述
货号ARO-A12462
品牌ProteoGenix
描述
Anti-Human MCM6 Polyclonal Antibody (ARO-A12462) is a rabbit polyclonal antibody detecting DNA replication licensing factor MCM6, p105MCM, MCM6 in ELISA, IHC, WB. Suitable for Rat, Bos taurus, Human, Mouse, Xenopus laevis, Xenopus tropicalis.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Rat, Bos taurus, Human, Mouse, Xenopus laevis, Xenopus tropicalis
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human MCM6 (Arg190-Thr661).
靶标DNA replication licensing factor MCM6, p105MCM, MCM6
纯化方式Purified by antigen affinity column.
Accession号Q14566
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

DNA replication licensing factor MCM6 is a ~92 kDa protein. Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.

1. Tsuji, T. et al. (2006) Molecular biology of the cell 17, 4459-72. PMID: 16899510
2. Rzechorzek, NJ. et al. (2020) Nucleic acids research 48, 6980-6995. PMID: 32453425
3. Jones, ML. et al. (2021) The EMBO journal 40, e108819. PMID: 34694004
4. Jenkyn-Bedford, M. et al. (2021) Nature 600, 743-747. PMID: 34700328
5. Baris, Y. et al. (2022) Nature 606, 204-210. PMID: 35585232
6. Ishimi, Y. (1997) The Journal of biological chemistry 272, 24508-13. PMID: 9305914
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-Human MCM6 Polyclonal Antibody

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