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Anti-Human ARL3 Polyclonal Antibody (ARO-A12454)

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概述
货号ARO-A12454
品牌ProteoGenix
描述
Anti-Human ARL3 Polyclonal Antibody (ARO-A12454) is a rabbit polyclonal antibody detecting ARFL3, ADP-ribosylation factor-like protein 3, ARL3 in ELISA, IHC, WB. Suitable for Bos taurus, Danio rerio, Human, Mouse, Pongo abelii, Rat, Pig, Taeniopygia guttata, Xenopus laevis.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Bos taurus, Danio rerio, Human, Mouse, Pongo abelii, Rat, Pig, Taeniopygia guttata, Xenopus laevis
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human ARL3 (Met1-Lys182).
靶标ARFL3, ADP-ribosylation factor-like protein 3, ARL3
纯化方式Purified by antigen affinity column.
Accession号P36405
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

ADP-ribosylation factor-like protein 3 (ARL3) is a ~20 kDa protein. Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins to the cilium, including myristoylated NPHP3 and prenylated INPP5E. Targets NPHP3 to the ciliary membrane by releasing myristoylated NPHP3 from UNC119B cargo adapter into the cilium.

1. Zhou, C. et al. (2006) Molecular biology of the cell 17, 2476-87. PMID: 16525022
2. Veltel, S. et al. (2008) FEBS letters 582, 2501-7. PMID: 18588884
3. Wright, KJ. et al. (2011) Genes & development 25, 2347-60. PMID: 22085962
4. Alkanderi, S. et al. (2018) American journal of human genetics 103, 612-620. PMID: 30269812
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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