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Anti-Human AGTPBP1 Polyclonal Antibody (ARO-A12469)

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概述
货号ARO-A12469
品牌ProteoGenix
描述
Anti-Human AGTPBP1 Polyclonal Antibody (ARO-A12469) is a rabbit polyclonal antibody detecting Cytosolic carboxypeptidase 1, Nervous system nuclear protein induced by axotomy protein 1 homolog, ATP/GTP-binding protein 1, CCP1, AGTPBP1, KIAA1035, NNA1 in ELISA, IHC, WB. Suitable for Human, Mouse, Chicken, Xenopus laevis, Xenopus tropicalis.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Chicken, Xenopus laevis, Xenopus tropicalis
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human AGTPBP1 (Glu706-Cys1030).
靶标Cytosolic carboxypeptidase 1, Nervous system nuclear protein induced by axotomy protein 1 homolog, ATP/GTP-binding protein 1, CCP1, AGTPBP1, KIAA1035, NNA1
纯化方式Purified by antigen affinity column.
Accession号Q9UPW5
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Cytosolic carboxypeptidase 1 (AGTPBP1) is a ~138 kDa protein. Metallocarboxypeptidase that mediates protein deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate. Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of alpha-tubulin as well as non-tubulin proteins such as MYLK. Involved in KLF4 deglutamylation which promotes KLF4 proteasome-mediated degradation, thereby negatively regulating cell pluripotency maintenance and embryogenesis.

1. Berezniuk, I. et al. (2012) The Journal of biological chemistry 287, 6503-17. PMID: 22170066
2. Berezniuk, I. et al. (2013) The Journal of biological chemistry 288, 30445-30453. PMID: 24022482
3. Shashi, V. et al. (2018) The EMBO journal 37. PMID: 30420557
4. Ye, B. et al. (2018) Nature communications 9, 1261. PMID: 29593216
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-Human AGTPBP1 Polyclonal Antibody

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