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Anti-MFN2 Polyclonal Antibody (ARO-A12652)

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概述
货号ARO-A12652
品牌ProteoGenix
描述
Anti-MFN2 Polyclonal Antibody (ARO-A12652) is a rabbit polyclonal antibody detecting Transmembrane GTPase MFN2, Mitofusin-2, KIAA0214, CPRP1, MFN2 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human MFN2 (His20-Arg400).
靶标Transmembrane GTPase MFN2, Mitofusin-2, KIAA0214, CPRP1, MFN2
纯化方式Purified by antigen affinity column.
Accession号O95140
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Mitofusin-2 (MFN2) is a ~86 kDa protein. Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion. Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events. Overexpression induces the formation of mitochondrial networks. Membrane clustering requires GTPase activity and may involve a major rearrangement of the coiled coil domains (Probable). Plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes.

1. Santel, A. et al. (2001) Journal of cell science 114, 867-74. PMID: 11181170
2. Rojo, M. et al. (2002) Journal of cell science 115, 1663-74. PMID: 11950885
3. Casasnovas, C. et al. (2010) Journal of medical genetics 47, 249-56. PMID: 19889647
4. Senyilmaz, D. et al. (2015) Nature 525, 124-8. PMID: 26214738
5. Cao, YL. et al. (2017) Nature 542, 372-376. PMID: 28114303
6. Chen, Y. et al. (2013) Science (New York, N.Y.) 340, 471-5. PMID: 23620051
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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