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Anti-Human CUL4B Polyclonal Antibody (ARO-A12641)

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概述
货号ARO-A12641
品牌ProteoGenix
描述
Anti-Human CUL4B Polyclonal Antibody (ARO-A12641) is a rabbit polyclonal antibody detecting Cullin-4B, CUL-4B, CUL4B, KIAA0695 in ELISA, IHC, WB. Suitable for Human, Mouse.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human CUL4B (Gly728-Ala913).
靶标Cullin-4B, CUL-4B, CUL4B, KIAA0695
纯化方式Purified by antigen affinity column.
Accession号Q13620
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Cullin-4B (CUL4B) is a ~103 kDa protein. Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit. CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation-induced DNA damage. Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication.

1. Higa, LA. et al. (2003) Nature cell biology 5, 1008-15. PMID: 14578910
2. Higa, LA. et al. (2006) Cell cycle (Georgetown, Tex.) 5, 71-7. PMID: 16322693
3. Wang, H. et al. (2006) Molecular cell 22, 383-94. PMID: 16678110
4. Guerrero-Santoro, J. et al. (2008) Cancer research 68, 5014-22. PMID: 18593899
5. Fischer, ES. et al. (2011) Cell 147, 1024-39. PMID: 22118460
6. Koren, I. et al. (2018) Cell 173, 1622-1635.e14. PMID: 29779948
7. Chen, SH. et al. (2018) The EMBO journal 37. PMID: 30166453
8. Maiani, E. et al. (2021) Nature 592, 799-803. PMID: 33854232
9. Chaikovsky, AC. et al. (2021) Nature 592, 794-798. PMID: 33854239
10. Sjögren, B. et al. (2015) PloS one 10, e0123581. PMID: 25970626
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-Human CUL4B Polyclonal Antibody

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