Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (SDHA) is a ~72 kDa protein. Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH also oxidizes malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate. Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerized into keto-oxaloacetate. Can act as a tumor suppressor.
1. Parfait, B. et al. (2000) Human genetics 106, 236-43. PMID: 10746566
2. Renkema, GH. et al. (2015) European journal of human genetics : EJHG 23, 202-9. PMID: 24781757
3. Burnichon, N. et al. (2010) Human molecular genetics 19, 3011-20. PMID: 20484225
