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Anti-Human CNOT1 Polyclonal Antibody (ARO-A12636)

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概述
货号ARO-A12636
品牌ProteoGenix
描述
Anti-Human CNOT1 Polyclonal Antibody (ARO-A12636) is a rabbit polyclonal antibody detecting Negative regulator of transcription subunit 1 homolog, hNOT1, NOT1H, CNOT1, CDC39, NOT1, CCR4-associated factor 1, KIAA1007, CCR4-NOT transcription complex subunit 1 in ELISA, IHC, WB. Suitable for Human, Mouse, Danio rerio, Xenopus tropicalis.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Danio rerio, Xenopus tropicalis
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human CNOT1 (Gln1356-Asp1607).
靶标Negative regulator of transcription subunit 1 homolog, hNOT1, NOT1H, CNOT1, CDC39, NOT1, CCR4-associated factor 1, KIAA1007, CCR4-NOT transcription complex subunit 1
纯化方式Purified by antigen affinity column.
Accession号A5YKK6
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

CCR4-NOT transcription complex subunit 1 (CNOT1) is a ~266 kDa protein. Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C.

NoteFor research use only.
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参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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