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Anti-Human PEX14 Polyclonal Antibody (ARO-A12624)

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概述
货号ARO-A12624
品牌ProteoGenix
描述
Anti-Human PEX14 Polyclonal Antibody (ARO-A12624) is a rabbit polyclonal antibody detecting Peroxisomal membrane protein PEX14, PTS1 receptor-docking protein, Peroxin-14, PEX14, Peroxisomal membrane anchor protein PEX14 in ELISA, IHC, WB. Suitable for Cricetulus longicaudatus, Human, Mouse, Rat.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Cricetulus longicaudatus, Human, Mouse, Rat
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human PEX14 (Arg25-Glu76).
靶标Peroxisomal membrane protein PEX14, PTS1 receptor-docking protein, Peroxin-14, PEX14, Peroxisomal membrane anchor protein PEX14
纯化方式Purified by antigen affinity column.
Accession号O75381
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Peroxisomal membrane protein PEX14 is a ~41 kDa protein. Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix. Plays a key role for peroxisome movement through a direct interaction with tubulin.

1. Neuhaus, A. et al. (2014) The Journal of biological chemistry 289, 437-48. PMID: 24235149
2. Dias, AF. et al. (2017) The Journal of biological chemistry 292, 15287-15300. PMID: 28765278
3. Fransen, M. et al. (1998) Proceedings of the National Academy of Sciences of the United States of America 95, 8087-92. PMID: 9653144
4. Bharti, P. et al. (2011) Journal of cell science 124, 1759-68. PMID: 21525035
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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