Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景
Pleiotrophin (PTN) is a ~18 kDa protein. Secreted growth factor that mediates its signal through cell-surface proteoglycan and non-proteoglycan receptors. Binds cell-surface proteoglycan receptor via their chondroitin sulfate (CS) groups. Thereby regulates many processes like cell proliferation, cell survival, cell growth, cell differentiation and cell migration in several tissues namely neuron and bone. Also plays a role in synaptic plasticity and learning-related behavior by inhibiting long-term synaptic potentiation. Binds PTPRZ1, leading to neutralization of the negative charges of the CS chains of PTPRZ1, inducing PTPRZ1 clustering, thereby causing the dimerization and inactivation of its phosphatase activity leading to increased tyrosine phosphorylation of each of the PTPRZ1 substrates like ALK, CTNNB1 or AFAP1L2 in order to activate the PI3K-AKT pathway.
1. Stoica, GE. et al. (2001) The Journal of biological chemistry 276, 16772-9. PMID: 11278720
2. Fukada, M. et al. (2006) FEBS letters 580, 4051-6. PMID: 16814777
3. Mikelis, C. et al. (2009) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 23, 1459-69. PMID: 19141530
4. Ryan, E. et al. (2016) The FEBS journal 283, 1488-503. PMID: 26896299
5. Kuboyama, K. et al. (2016) The Journal of biological chemistry 291, 18117-28. PMID: 27445335
6. Wellstein, A. et al. (1992) The Journal of biological chemistry 267, 2582-7. PMID: 1733956
