Affinity Purified — Minimal background and high purity for reliable results.
Multi-Application — Validated across multiple applications.
Multi-Species — Cross-reactive for translational research.
种属反应性
Human, Mouse, Rat, Equus caballus, Chicken, Mesocricetus auratus, Nannospalax galili, Pongo abelii, Tyto alba
应用
ELISA, IHC, WB
宿主
Rabbit
同种型
IgG
克隆类型
Polyclonal
免疫原
E. coli - derived recombinant Human ARNTL (Glu48-Leu320).
靶标
Basic-helix-loop-helix-PAS protein MOP3, ARNTL, Member of PAS protein 3, PAS domain-containing protein 3, BMAL1, Aryl hydrocarbon receptor nuclear translocator-like protein 1, BHLHE5, Class E basic helix-loop-helix protein 5, bHLHe5, MOP3, Brain and muscle ARNT-like 1, bHLH-PAS protein JAP3, PASD3
Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景
Basic helix-loop-helix ARNT-like protein 1 (ARNTL) is a ~68 kDa protein. Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers').
1. Wang, Z. et al. (2013) Cell research 23, 213-24. PMID: 23229515
2. Lin, R. et al. (2017) Molecular cell 68, 198-209.e6. PMID: 28985504
